ODP417 Kisspeptin directly stimulates estrogen and progesterone secretion from human granulosa cells.

Abstract Kisspeptin is a peptide hormone that has central role to stimulate gonadotropin-releasing secretion from the hypothalamus. Furthermore, it was shown have peripheral roles on enhancing CYP19 (aromatase) expression and aromatase human granulosa cells (1). The objectives of this study were determine direct effects kisspeptin treatment estrogen progesterone granulosa-like tumor cell line (KGN). KGN (n=3) treated with 10 nM follicle stimulating (FSH); 100, 1,000, 10,000 kisspeptin; FSH together different doses for 24 hours. Estrogen concentrations in supernatant measured by enzyme immunoassay kits. results showed alone (P<0. 05) 100 01), 1,000 001), 001) increased supernatants when compared control. did not increase Interestingly, at 01) enhanced alone. All Only 01). Taken together, stimulated these addition Further studies are required whether can restore functions unresponsive or partially responsive aging humans secrete as well useful augmenting infertility treatment. Reference: (1) Qin L, Sitticharoon C, Petyim S, Keadkraichaiwat I, Sririwichitchai R, Maikeaw P, et al. Exp Biol Med (Maywood). 2021;246(8): 996-1010. Presentation: No date time listed